Software Complete List of Publications Current Projects Overview
Arthur Salomon Curriculum Vitae
 Index
Education
Case Western Reserve University, B.S., 1995, Chemistry
Stanford University, Ph.D., 2000, Biological Chemistry (C. Khosla)
       Thesis: "Chemistry and Biology of Apoptolidin, an Inhibitor of F0F1-ATPase that
       Selectively Induces Apoptosis"
Genomics Institute of the Novartis Research Foundation (GNF), San Diego, Postdoctoral
       Research Associate, 2000-04, Proteomics (P. Schultz)
Professional Experience
2000-04   Research Associate, GNF, San Diego
2004-       Assistant Professor, Molecular Biology, Cell Biology, and Biochemistry (MCB) ,                 Brown University Medical School
Current Teaching
2006-      Introductory Biochemistry (Biol0280) - http://bi28.info/
Publications
29. K. Yu, A. Salomon (2010). "HTAPP: High-throughput autonomous proteomic pipeline." Proteomics, in Press. (Paper supplemental website)
28. R. Jianu, K. Yu, L. Cao, V. Nguyen, A. Salomon, D. Laidlaw (2009). "Effective visual integration of quantitative proteomic data, pathways, and protein information." Trans. on Vis. and Comp. Graphics, in Press.download pdf (Paper supplemental website)
27. K. Yu, A. Salomon (2009). "PeptideDepot: Flexible relational database for visual analysis of quantitative proteomic data and integration of existing protein information." Proteomics, 9(23), 5350-58.download pdf (Paper supplemental website)
26. V. Nguyen, L. Cao, J. T. Lin, N. Hung, A. Rit, K. Yu, R. Jianu, B.J. Raphael, S. Ulin, D.H. Laidlaw, L. Brossay, A. Salomon (2009). "A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation." Mol. Cell Prot, 8:2418-31.download pdf (Paper supplemental website)
25. K. Yu, A. Sabelli, L. DeKeukelaere, R. Park, S. Sindi, CA. Gatsonis, A. Salomon (2009). "Integrated platform for manual and high-throuput statistical validation of tadem mass spectra." Proteomics, 9(11), 3115-25.download pdf (Paper supplemental website)
24. I. Lee, A. Salomon, K. Yu, L. Samavati, P. Pecina, A. Pecinova, M. Huttemann (2009). "Isolation of regulatory-competent, phosphorylated cytochrome c oxidase." Methods Enzymol. 457, 193-210.download pdf
23. J. Pezza, S. Langseth, R. Yamamoto, S. Dorris, S. Ulin, A. Salomon, T. Serio (2009). "The NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype." Molec. Biol. Cell.20(3) 1068-80download pdf
22. A. Ritz, G. Shakhnarovich, A. Salomon, B. Raphael (2009). "Discovery of phosphorylation motif mixtures in phosphoproteomics data." Bioinformatics. 25 (1) 14-21.download pdf
21. H. Yu, I. Lee, A. Salomon, K. Yu, M. Huttmann (2008). "Mammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration." Biochim. Biophys. Acta. 1777(7-8) 1066-71. download pdf
20. L. Cao, K. Yu, C. Banh, V. Nguyen, A. Ritz, B. Raphael, Y. Kawakami, T. Kawakami, A. Salomon (2007). "Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling." J. Immunology. 179(9) 5864-76. download pdf (Paper supplemental website)
19.

T. Nuhse, K. Yu, A. Salomon (2007). “Isolation of Phosphopeptides by Immobilized Metal Ion Affinity Chromatography.”  In Cur. Prot. Mol. Biol., (Ausubel et al., eds.) 18.13.1-18.13.23. John Wiley & Sons, Hoboken, N.J.download pdf

18.

L. Cao, K. Yu, A. Salomon (2006). “Phosphoproteomic Analysis of Lymphocyte Signalling.” In Advances in Experimental Medicine and Biology, Vol. 584, C. Tsoukas, ed. Springer, New York, NY. chapter 19, Pgs. 277-88.download pdf

17.

I. Lee, A. Salomon, K. Yu, J. Doan, L. Grossman, M. Huttemann (2006). “New Prospects for an Old Enzyme: Mammalian Cytochrome c Is Tyrosine Phosphoryalted In Vivo.” Biochemistry. 45(30): 9121-9128.download pdf

16.

S. Ficarro, A. Salomon, L. Brill, D. Mason, M. Stettler-Gill, A. Brock, E. Peters (2005). “Automated immobilized metal affinity chromatography/nano-LC electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.” Rap. Comm. Mass Spec. 19:57-71.

15.

I. Lee, A. Salomon, S. Ficarro, I. Mathes, F. Lottspeich, L. Grossman, M. Huttemann (2005). “cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity.” J. Biol. Chem.280:6094-6100.

14.

L. Brill, A. Salomon, S. Ficarro, M. Mukherji, M. Stettler-Gill, E. Peters (2004). “Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.” Anal. Chem. 76(10): 2763-2772.

13.

A. Brock, D. Horn, E. Peters, C. Shaw,  C. Ericson, Q. Phung, A. Salomon (2003). “An automated matrix-assisted laser desorption/ionization quadrupole fourier transform ion cyclotron resonance mass spectrometer for ‘bottom up’ proteomics.” Anal. Chem. 75(14):3419-3428.

12.

C. Ericson, Q. Phung, D. Horn, E. Peters, J. Fitchett, S. Ficarro, A. Salomon, L. Brill, A. Brock (2003). “An automated noncontact deposition interface for liquid chromatography matrix-assisted laser desorption/ionization mass spectrometry.” Anal. Chem. 75(10): 2309-2315.

11.

A. Salomon, S. Ficarro, L. Brill, A. Brinker, Q. Phung, C. Ericson, K. Sauer, D. Horn, P. Schultz, E. Peters (2003). “Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.” Proc. Nat. Acad. Sci., 100(2): 443-448.

10.

A. Brock, D. Horn, C. Shaw, E. Peters, C. Ericson, Q. Phung, S. Ficarro, A. Salomon (2002). “FT-ICR MS Platform for Proteomics: Automated High Performance Mass Spectrometry and Data Analysis” Am. Pharma. Rev., 5(4): 94-99.

9.

E. Peters, A. Brock, Q. Phung, J. Fitchett, D. Horn, C. Ericson, S. Ficarro, A. Salomon (2002). “Automated Liquid Chromatography MALDI FT-ICR MS Platform for Proteomics: Rationale for an Off-Line Approach and Optimized Implementation” Am. Pharma. Rev., 5(3): 72-81.

8.

E. Peters, A. Brock, D. Horn, Q. Phung, C. Ericson, A. Salomon, S. Ficarro, L. Brill (2002). “An automated LC-MALDI FT-ICR MS platform for high-throughput proteomics.” LCGC Europe, 15(7): 423-8.

7.

J. Pennington, H. Williams, A. Salomon, G. Sulikowski (2002). “Toward a stable apoptolidin derivative: Identification of isoapoptolidin and selective deglycosylation of apoptolidin.” Organic Letters, 4(22): 3823-3825.

6.

A. Salomon, Y. Zhang, H. Seto, C. Khosla (2001). "Structure-activity relationships within a family of selectively cytotoxic macrolide natural products.” Organic Letters, 3(1): 57-59.

5.

A. Salomon, D. Voehringer, L. Herzenberg, C. Khosla (2001). "Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase." Chemistry and Biology, 8(1): 71-80.

4.

A.Salomon, D. Voehringer, L. Herzenberg, C. Khosla (2000). "Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F0F1-ATPase.” Proc. Nat. Acad. Sci., 97(26): 14766-71.

3.

H. Zeng, H. Shao, N. Menon, J. Yang, A. Salomon, R. Freidland, and M. Zagorski (2000). “Nicotine and Amyloid Formation” Biological Psychiatry 49(3): 248-257.

2. H. Shao, K. Marcinowski, E. Clancy, A. Salomon and M. Zagorski (1997). “The Solution Structures of the ß-Amyloid Peptide Provide a Molecular Approach for the Treatment of Alzheimer’s Disease.” In K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H. M. Wisniewski (eds), Alzheimer’s Disease: Biology, Diagnosis and Therapeutics New York, John Wiley & Sons, pp 729-739.
1. A. Salomon, K. Marcinowski, R. Friedland, and M. Zagorski (1996). “Nicotine inhibits amyloid formation by the beta-peptide.” Biochemistry 35(42): 13568-78.
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News & Views

Bonetta, Laura (2005). "Probing the kinome.” Nature Methods, 2: 225-232.
-This review describes among other things, methodology originally developed at GNF which we have adopted here at Brown

Talks and Posters

55th ASMS Conference on Mass Spectrometry and Allied Topics
Poster: “Quantitative, time-resolved phosphoproteomic analysis of mast cell signaling”, Indianapolis, IN, June 2007

55th ASMS Conference on Mass Spectrometry and Allied Topics
Poster: “A software suite to expedite the study of cell signaling pathways: automated acquisition, organization, and annotation”, Indianapolis, IN, June 2007

MCB Departmental Seminar
Invited Talk: “Phosphoproteomic Analysis of Cellular Signaling”
LMM, Brown University, October 11, 2006

Brown Chemistry Department
Invited Talk: “Phosphoproteomics: Unravelling Nature’s Complexity”
Provdience, RI May 2, 2006

Marine Biological Laboratory
Invited Talk: “Phosphoproteomic analysis of signaling pathways”
Woods Hole, MA April 14, 2006

Allergy/Immunology Grand Rounds, Brown Medical School
“Phosphoproteomic analysis of mast cell signaling”
Rhode Island Hospital, Providence, October 20, 2005

COBRE CCRD Third Annual Research Symposium
Invited Talk: “Unraveling the molecular circuitry of cells and disease using phosphoproteomics”
Rhode Island Convention Center, Providence, June 24, 2005.

3rd Lymphocyte Signal Transduction Workshop
Invited Talk: “Unraveling molecular circuitry in immunological signaling cascades using phosphoproteomics”
Crete, Greece, May 31, 2005

Proteomicsn Montreal Spring seminar
Invited Talk: “Phosphoproteomics on steroids: Application of LTQ-FT accurate mass to the manual validation problem”
Montreal and Toronto, Canada, May 18, 2005

Institute for Diabetes, Obesity, & Metabolism seminar series
Invited Talk: “Unraveling the molecular circuitry of cells using phosphoproteomics”
University of Pennsylvania, February 15, 2005

Center For Genomics and Proteomics Inaugural Symposium
Invited Talk: “Unraveling the molecular circuitry of cells using phosphoproteomics”
LMM, Brown University, January 28, 2005

52nd ASMS Conference on Mass Spectrometry and Allied Topics
Talk: “Unraveling the Molecular Circuitry in Immunological Signaling Cascades Using Phosphoproteomics”, Nashville, TN, May 2004

52nd ASMS Conference on Mass Spectrometry and Allied Topics
Poster: “IMAC Enrichment of Phosphopeptides From Complex Mixtures: To Methylate or Not to Methylate”, Nashville, TN, May 2004

227th ACS National Meeting
Invited Talk: “High-throughput phosphoproteomics: Unraveling the molecular circuitry of the human cell”, Anaheim, Ca, March 2004


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